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The article says the pace of escalation matters most, because a slower ramp gives the digestive system more time to adapt

Dry mouth is less frequently reported than gastrointestinal side effects but may also include bad (sulphur-smelling) breath

A lobular/clustered tumor cell arrangement with syncytial-like cytology, psammoma bodies, and fat accumulation may also help distinguish MMNST from melanoma [9]

The resulting inflammation exacerbates tissue damage and contributes to adverse remodeling of the heart, which can lead to heart failure if not properly managed [93]