Limit of detection (LOD) and limit of quantification (LOQ) Limit of detection (LOD) is the lowest amount or concentration of an analyte (substance being measured) that can be detected with reasonable certainty by the analytical method
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Likewise, in addition to the mentioned Parkinsons disease models [198,199,200], these were induced by various central causes (e.g., spinal cord compression [170,230], stroke [145], traumatic brain injury [231], neurotoxin cuprizone that mimics multiple sclerosis in rats [232], neuroleptics [199,200], amphetamine [200,233], alcohol acute and chronic intoxication [234], serotonin syndrome [235], and NO-system blockade [200])
Unlike oral supplements, which face the gauntlet of our digestive system (and often get broken down, resulting in as little as 20-50% absorption), intravenous delivery bypasses the gut entirely