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03 Research Highlights Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade 04 Dosage Administration & Timing Oral administration (capsule or solution) or Subcutaneous (SC) injection into abdominal or gluteal subcutaneous tissue

Structural and metabolic changes in Atp7b/ mouse liver and potential for new interventions in Wilsons disease

doi:10.1158/1078-0432.CCR-08-2503