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Introduction Autoimmune thyroid diseases (AITD), namely autoimmune thyroiditis (AIT)/Hashimotos thyroiditis (HT), Graves disease (GD), Graves ophthalmopathy (GO), are complex, polygenic lesions with both similarities and differences that largely programmed by genetic factors ( The prevalence of hyperthyroidism is 1.2-1.6%, of which 0.5-0.6 are obvious and 0.7-1% are subclinical ( Treatment of TG of patients with HT is not effective enough