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Of note, however, in a 40 week Phase 3 study of overweight/obese individuals with type 2 diabetes, 36 mg of orforglipron taken orally once daily achieved reductions in HbA 1c of ~12 mmol/mol (1.07%) and in body weight of 5.9 kg (placebo subtracted) with an adverse event profile similar to that of the established GLP-1RA class [83]

While having problems such as burping or other signs in the digestive tract may mean Mounjaro is doing something in the tract, these side effects do not always tell you if the treatment is really working

Yet, not enough B12 can cause serious problems like nerve issues and anemia

Murao A, Brenner M, Aziz M, Wang P