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In the comparison with dulaglutide 3 mg, increased treatment costs were entirely offset by cost savings from avoidance of diabetes-related complications (most notably cardiovascular complications, with mean cost savings of GBP 62 per patient), while in the comparison with dulaglutide 4.5 mg, increased treatment costs were partially offset by the avoidance of complications (most notably by ophthalmic complications, with mean cost savings of GBP 27 per patient)