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Best for: People looking at the global pipeline of alternatives and considering future options with strong metabolic profiles
This stems from early studies in rodents (rats and mice) which showed that GLP-1 medications could lead to the development of thyroid C-cell tumours, including a rare type called medullary thyroid carcinoma (MTC)
Through establishing an interleukin (IL)-1-stimulated chondrocytes, it was found that L-theanine could inhibit the nuclear factor kappa B (NF-B) pathway, thereby reducing the expression of proinflammatory factors, including cyclooxygenase-2 (COX-2), prostaglandin E2, inducible nitric oxide synthase, as well as NO, and protect the degradation of extracellular matrix (29)
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