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Other effects on transcription have also been described via activation of mitogen activated protein kinases (MAPKs) (Leinninger, Backus, Sastry et al., 2005, Palacios, Sanchez-Franco, Fernandez et al., 2005, Song, Li, Du et al., 2005) which relay hypertrophic signals to myonuclei after contraction

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Yet decades later, researchers still do not have a clear understanding of how DSIP may work, whether it has a meaningful physiological role in humans, or whether the early findings represent a reproducible biological effect