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This complexity necessitates precision targeting strategies that consider spatial and temporal factors, rather than generalized immunomodulation

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The cornea of the eye harbors a rich array of immune cells and nerve fibers, making it susceptible to characteristic changes induced by systemic autoimmune and vasculitic diseases, resulting in corneal manifestations like immune cell infiltration, alterations in nerve fibers leading to changes in corneal mucosal tissues, decreased tear secretion, modifications in meibomian gland structure and function manifesting as symptoms and signs of dry eye syndrome, posing challenges in treatment [310]

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