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Thus, both represent potential targets for the prevention of the hyperglycemia associated with diabetes and impaired insulin function

The safety and pharmacodynamic results in the multiple-dose trial must be interpreted in light of the high dose levels (2040 mg oral semaglutide) and the relatively fast initial dose escalation in this trial compared with the phase III trials, where dose levels of 314 mg oral semaglutide are investigated and a slower initial dose escalation is used to minimise gastrointestinal adverse effects

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Additionally, Semaglutide is not recommended for individuals with a history of pancreatitis, as there is a slight risk of pancreatic inflammation associated with GLP-1 receptor agonists