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Hyperammonemia, the last indication of high-volume hemodiafiltration in adult and children: a structured review

In addition, the transition from laboratory-scale research to clinical application faces substantial barriers, including extensive preclinical testing to establish safety and efficacy, the complexities of large-scale manufacturing to ensure consistent quality, and the rigorous regulatory approval processes that demand considerable time and resources (Oliva et al., 2021

Nat Rev Cardiol (2019) 16(4):20312

Because sublingual bioavailability is lower than injection bioavailability, the actual milligram dose in the drops is higher than the equivalent injectable dose