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[15] [13] Other notable adverse effects include: Hypoglycemia : Low risk when used as monotherapy, but increased when combined with insulin or sulfonylureas Injection site reactions : Erythema, pruritus, or discomfort in approximately 2% to 4% of patients Fatigue and dizziness : Reported in 5% to 8% of participants Increased heart rate : Mean increases of 2 to 4 beats per minute observed [1] [2] Serious adverse events were uncommon but included acute pancreatitis (approximately 0.2% incidence), gallbladder disease including cholecystitis and cholelithiasis (0.6% in diabetes trials and up to 2.5% in weight management trials, associated with rapid weight loss), and acute kidney injury, typically in the context of severe dehydration from gastrointestinal symptoms

Oxytocin levels and IR in PWS Several studies have investigated alterations of oxytocin (OXT) in PWS patients

Potential risks include: Changes in moles - new or rapidly changing moles have been reported in people using melanotan alongside UV exposure, which is concerning from a skin cancer perspective

Safety evaluation of EGCG-Zn suppositories To evaluate the long-term safety of EGCG-Zn suppositories, mice were subjected to rectal administration for 30 days (once every three days, Fig