1,2 As such, this HF subtype imposes tremendous economic burden on the health care system in addition to its impact on mortality, morbidity and quality of life of affected patients
And in short that came out a few years after that STEP 1 trial what we did for the very first time is take individuals with obesity and pre-existing cardiovascular disease, like a prior stroke, prior heart attack, or peripheral arterial disease, called PAD, and they're on maximal therapy for their cardiovascular disease or stroke, and then randomized them on top of that to either semaglutide or placebo
It wasnt in the textbooks, and it wasnt in the medical journals
Additionally, the reduction in vascular smooth muscle sympathetic nerve activity induced by NPY facilitates increased blood flow to the gastrointestinal tract and liver, thereby enhancing digestion and absorption (81)