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By year 2, headache rates were identical in both groups, indicating that the medication-related excess seen in shorter trials doesnt persist long term

Most notable, there were only few eligible RCTs included in this meta-analysis and most of them had a relatively modest number of participants

Insulin replacement therapy regimens in T2DM In patients with T2D who fail to achieve glycemic targets despite optimization of basal insulin, structured intensification of therapy becomes necessary