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The statistical analysis was performed using XLStats 2017 software (Addinsoft, New York, NY)

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Bouch N, Fait A, Bouchez D et al (2003) Mitochondrial succinic-semialdehyde dehydrogenase of the -aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants

Clinicians must take into account mechanisms of action, level of HbA1c reduction, impact on fasting plasma glucose and/or post-prandial glucose levels, safety and tolerability, effects on weight, route of administration, and finally, cost