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In RPE cells, it plays a key role in proliferative retinal diseases, such as age-related macular degeneration, by contributing to subretinal fibrosis [32]
AIs can be divided into two groups based on their chemical structure: steroidal (analogs of androstenedione, exemestane, formestane, and testolactone), which provide irreversible aromatase inhibition, and non-steroidal (anastrozole and letrozole), which provide reversible inhibition (Ahmad, 2015)
Other investigations examine cellular signaling, circadian regulation, and intracellular physiology
