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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

The studies documenting hair-relevant effects DPC proliferation, follicle elongation, stem cell recovery used direct tissue contact, which topical application most closely replicates

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Human cystic fibrosis airway epithelia have reduced Cl conductance but not increased Na + conductance