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Physiol Rev 2010;90:47112

New Kid on the Block - Retatrutide for Obesity Management Kimmy Nguyen Dec 10, 2025 6 min read Written by Mariana Lopez, PharmD Candidate 2026 and Adenike Atanda-Oshikoya PharmD, BCACP, CDCES, CTTS Background on Obesity and Comorbidities Obesity, as defined by the World Health Organization (WHO), is the excessive and unhealthy accumulation of body fat.(1) Severe obesity is strongly associated with comorbid conditions such as type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), heart failure, chronic liver disease, and reduced life expectancy.(2) In addition to the clinical implications, obesity poses a substantial economic burden

Severe cases can develop into chronic ulcers, strictures, and even perforations, significantly impacting patients quality of life and treatment compliance [4,5,6]