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This metabolic pathway has been associated with an increased risk of coronary heart disease 29 .Although blood TMAO and gut microbe-derived metabolites, such as TML and GBB, are not associated with thrombosis in venous thromboembolism (VTE) 30 , GBB has been shown to prevent myocardial infarction by inhibiting l-carnitine (L-CN) synthesis, limiting long-chain fatty acid oxidation, and promoting glucose metabolism 31

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Higher concentrations appeared to be affected by the natural yellow color of PHP resulting in inconclusive, or noisy, readings

CO suppresses NLRP3 inflammasome activation, reduces pyroptosis, scavenges ROS, and enhances DNA repair, while Mn alleviates hypoxia via HO-to-O conversion and downregulates fibrotic markers (e.g., TGF-1, -SMA)