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These include patients with histories or predisposal towards renal failure, biliary disease, thyroid cancer, diabetic retinopathy, and pancreatitis

Clinical Evidence# Afamelanotide Clinical Trials# Multiple Phase 2 and Phase 3 trials have evaluated afamelanotide: EPP Phase 3 (CUV039) : Randomized, double-blind, placebo-controlled trial in 93 EPP patients