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As GLP-1 drug use expands beyond controlled trial settings and into employer-sponsored plans, Medicaid programs, and state-regulated markets, attention increasingly shifts from efficacy to accesshow many patients receive these therapies, under what conditions, and at what cost

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However, these methods capture only a portion of the complexity of cellular regulation, as a substaintial fraction of human biology is governed at the proteome level through PTMs, which dynamically modulate protein structure, function and interactions in ways not captured by genetic approaches