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doi: 10.1007/s00253-020-10896-2

In addition, the choice of animal age is also very important because we need to select experimental animals that represent an age that is similar to human adults

Its comparison table lists their typical clinical use as cardiovascular and renal protection, and calls them complementary to incretin therapy rather than a direct substitute

If you develop a persistent, unexplained change in bowel habit particularly if you are aged 40 or over or have other risk factors your GP may wish to assess you in line with NICE guidance on suspected cancer (NG12), which sets out referral thresholds for persistent bowel changes