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In preclinical models, BPC-157 has been investigated for its influence on angiogenic signaling, nitric-oxidelinked pathways, and fibroblast activity associated with tendon and ligament biology [1][6][11]

i.e., liver blood flow decreased by 39% when pneumoperitoneum increased from 10 to 15 mmHg and liver ischemic injury occurred (Chen et al., 2017)

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