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Persistent hyperglycemia, a hallmark of diabetes and insulin resistance, initiates the Maillard reaction, a non-enzymatic chemical process in which reducing sugars react with amino groups on proteins and lipids, resulting in the formation of AGEs (106)

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TPT falls into the top right quadrant, indicating that, while it contains a high amount of predicted epitope content, its epitopes were highly conserved with epitopes derived from the human proteome