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We modeled the independent effect of the budget neutrality adjustments and the OPD fee schedule increase factor by using the relative payment weights and wage indexes for each year and using a CY 2025 conversion factor that included the OPD fee schedule increase and a budget neutrality adjustment for differences in wage indexes

Meanwhile, weight loss with CagriSema (15.6%) was statistically greater than both cagrilintide (8.1%) and semaglutide (5.1%)