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Dysfunction of BMSCs reduces their osteogenic differentiation and proliferative capacity, thereby compromising osteoblast formation and contributing to age-related declines in bone formation ( Method As shown in Figure 2 , a systematic review of recent research for ferroptosis and osteoporosis was conducted using the PubMed and Embase search engines from 1 January 1, 2019 to February 20, 2025

Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D

A posterior article studied the reproducibility of event adjudication of RELAX-AHF-EU and found a discordance of 55% between the RELAX-AHF-EU adjudication and the re-adjudication [47]