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However, the pivotal 36-week Phase 2 trial showed a larger range of mean loss, from 9.4% to 14.7%, across doses, confirming robust dose-dependent effects

130,218 At the molecular level, GLP-1 activates the cAMP response element-binding protein (CREB) via its receptor (GLP-1R), a transcription factor crucial for expressing the insulin gene

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Signs of dehydration include decreased urine output, dark urine, dizziness, and dry mouth