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Enrichment analysis was then performed on these human disease-associated proteins using Homo sapiens pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database via ClueGO 29 (adjusted p -value 0.05, Bonferroni step-down correction)

Quick Answer: Tirzepatide and metformin can be safely combined for enhanced weight loss and glycemic control, with tirzepatide providing potent appetite suppression (15-22% weight reduction) and metformin offering insulin-sensitizing effects and modest additional weight loss (2-3%)

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