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All animal experiments conducted in our laboratory and presented in this manuscript adhered to the Guidelines for the Care and Use of Laboratory Animals as required by the National Institutes of Health (NIH Publication No

Furthermore, it boasts improved tissue penetration and reduced toxicity due to its targeted delivery, making it a promising antitumor agent that could potentially overcome the limitations of traditional monoclonal antibodies, which may not elicit a response in all patients (Sioud et al., 2015)

Although hepatitis A, B, C, D, and E differ etiologically and phenomenologically, the clinical symptoms of hepatitis viruses are comparable, with hepatitis B and C being particularly linked to the development of liver fibrosis, HCC, and intrahepatic cholangiocarcinoma (Zhang et al., 2022)

D.CordesS.TaylorT.ColesW.RoskomK.LinkM.et al (2017)