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I think heat intolerance is very closely related I think it's a mast cell phenomenon

And only with enough of this molecule can the body function optimally

He noted that the number would be even higher if it were an exclusively female sample and said it's "a signal worth investigating." The study found that approximately 44 percent of users reported at least one side effect, most commonly gastrointestinal issues, including 37 percent reporting nausea, which "shows that the method is picking up a real signal," according to Sharath Chandra Guntuku, the study's senior author

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