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Immune recognition has not been completely eliminated by attempts to lessen this such as encasing nanoparticles with polyethylene glycol which may occasionally exacerbate inflammatory reactions [301]

In my clinical experience, patients with tendinopathy lasting 6-24 months often report: Significant pain reduction by week 2-3 Improved load tolerance during physical therapy by week 4-6 Return to prior activity levels (with appropriate rehab) by week 10-14 Ligament Injuries Partial ligament tears (ankle sprains, knee MCL/LCL sprains, wrist sprains) often leave residual instability and chronic pain

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Some patients require feeding tubes