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While mammals have only one copy of the GPX4 gene, fish have two copies, GPX4a and GPX4b

OA is characterized by progressive loss of cartilage extracellular matrix (ECM) and pathological changes in other joint tissues such as subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31

Less common side effects Beyond the gastrointestinal basics, tirzepatide can cause other effects that catch some members off guard: Fatigue is reported by a meaningful subset of users, particularly in the early weeks