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Data directionally consistent with Finnigan et al

P., & Deutz, N

On the other hand, in ischemia/reperfusion (I/R) model, it is well-known that ROS production and the subsequent secretion of TNF- by inflammatory cells significantly contributes to the injury, and preconditioning by short-term ischemia increases resistance to subsequent lethal ischemia/reperfusion with the suppression of massive inflammatory activation

For tumors expressing wild-type p53, therapeutic approaches aim to inhibit wild-type p53 degradation by disrupting the interaction between p53 and MDM2/4