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89 Importantly, restoration of hypothalamic autophagy via nutritional interventions such as docosahexaenoic acid-acylated astaxanthin monoester (AST-DHA) supplementation or genetic activation of Atg5 ameliorates obesity and improves glucose metabolism in experimental models, 90 demonstrating that hypothalamic autophagy is not merely correlative but mechanistically regulatory

One company is Zealand Pharma, which presented mid-stage data from a drug called petrelintide that it's developing with Roche

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5,186,326 By blocking the 5-HT3 receptor, alosetron modulates visceral sensation and reduces colonic motility