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Preclinical studies have found that Ex-4 significantly upregulates Sirt3 expression in glioblastoma by activating the GLP-1R, which subsequently inhibits the growth, migration, invasion, and epithelial-mesenchymal transition of glioma cells [87]
When the epidermis is involved, Spitz nevi often show epidermal thickening with elongated rete ridges and hyperkeratosis
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