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In fact, combinations are conceivable: e.g

Lung cancer occurrencecorrelation with serum chromium levels and genotypes

However, different investigations showed that xCT overexpression enhances cell dependency to glutamine or glucose [56-58]

The sorbitol/polyol pathway is similarly increased in the high glucose state, where sorbitol is, in turn, converted to fructose by sorbitol dehydrogenase (SDH), resulting in the production of 3-deoxyglucosone (3DG), a highly reactive -oxo-aldehyde, and promoting the production of AGEs