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and innate immunity - natural killer cells (NK-cells), neutrophils, natural Treg (nTreg), which interact and are mutually regulated, play a significant role ( The clinical manifestation of the autoimmune phenotype towards HT or GD largely depends on the balance of the immune response induced by T-helper cells (Th1 or Th2), antigen-presenting cells (APCs) and the cytokine profile that dominates at that moment in the thyroid parenchyma ( In HT patients, primary hypothyroidism occurs after the destruction of CD8 + and MF directly or with the help of released cytokines by NK-cells in ADCC (antibody-dependent cell-mediated cytotoxicity) of a sufficient number of follicular cells that produce TG ( Figure 1
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The challenge for clinicians and patients is to distinguish between peptides whose benefits and risks are well-characterized and those that are still, in truth, experimental agents being marketed as finished therapies
Kosfeld et al., 2005
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