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In terms of safety, the optimization of the delivery system resulted in a significant reduction of irritation in the compounded formulation, with the main adverse effects identified in the trials being transient erythema (5.2%) and dry skin (2.1%) (Palliyage et al., 2021)

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Finally, it is called an optic neuropathy because it is an injury to the optic nerve, which disrupts the ability of eye to send information to the brain

Melatonin patches typically start releasing melatonin within 30 minutes of application, but effects can vary