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the differential response at dynamic PDU in mildmoderate and severe vasculogenic ED highlighted by the current study might rely on an insufficient intracavernous l-ARG delivery, upon oral administration of l-ARG at the tested doses, unable to counteract a severe vascular impairment, therefore suggesting the potential requirement of higher l-ARG supplementation regimens in these patients, although in some cases of severe vasculogenic ED an irreversible vascular damage cannot be ruled out

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Subjects then engaged in a moderate 5-week exercise training program twice per week with the final training session on the fifth week of supplementation consisting of a supervised lower-body exercise challenge specifically constructed to induce muscle damage