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Some signs of B12 deficiency: Anemia (megaloblastic) Gastrointestinal lesions Poor nerve health Numbness/tingling sensation Memory loss, disorientation Weakness Personality and mood changes (including depression, dementia) Difficulty waking Some risks for B12 deficiency: Vegetarian, vegan, or low animal product diets Aging Males Caucasian and Latin American descent Malabsorption issues Pregnancy Alcoholism Small bowel resection or stomach surgery What is Vitamin D3