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Wall RT, Harlan JM, Harker LA, and Striker GE (1980)

Fundamentally, aging is driven by the cumulative effects of cellular senescence ( The strategies to address senescent cells and replenish exhausted stem cells during the aging process, as well as supplementing metabolic substances like NAD+, gene therapy, or epigenetic approaches to mitigate aging, are different because they aim to promote the repair of senescent cells rather than inducing their apoptosis ( The Forkhead box O (FOXO) proteins are an important subclass of the Forkhead family

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Specifically, GLP-1 and GIP are cleaved into two biologically inactive forms, GLP-1 937 (or GLP-1 936 ) and GIP 342