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Tirzepatide's binding kinetics at GLP-1R result in lower beta-arrestin recruitment relative to cAMP generation, a biased agonism profile, which may partly explain the sustained glucose-lowering effect observed across 40 weeks in SURPASS-2 [19]

Journal of Ultrasound in Medicine , 30(9), 1207-1213

In this study, we reported two cryo-electron microscopy (cryo-EM) structures of the active ghrelin receptorG q complexes bound to ghrelin and GHRP-6, respectively

NCBI Bookshelf, 2024 Jan