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High levels of SST5TMD4 are correlated with poor responsiveness to SS analogs even in the presence of a high expression of SSTR2 (49), suggesting a dominant-negative effect of this truncated isoform of SSTR5 on SSTR2-mediated signaling

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That dual mechanism is part of why we see such meaningful results in clinical trials, with patients losing up to about 21 percent of their body weight when combined with lifestyle changes. While often associated with weight loss, Zepbound may also support better blood sugar, cholesterol and blood pressure levels, and it can even help manage conditions like fatty liver and sleep apnea, says Dr