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In 2018, Amazentis SA received a favorable Generally Recognized As Safe (GRAS) review of Mitopure from the FDA

Certain agents, including semaglutide and liraglutide, are additionally indicated for longterm weight management in individuals with obesity or overweight, typically in the presence of at least one weightrelated comorbidity

Research suggests that similar to -MSH, MT-1 primarily targets melanocortin 1 receptors (MC1R) on melanocytes, potentially supporting melanin synthesis and pigmentation, thus reducing UV-induced damage to the stratum corneum

While this reclassification primarily targeted licensed compounding pharmacies, it sent a clear regulatory signal to the broader research vendor market: peptide compounds were attracting federal scrutiny at an unprecedented level