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In many cases, biological activity has been evaluated mainly through in vitro metabolic assays and a limited set of cellular models, which complicates the establishment of firm conclusions regarding their mechanisms of action and actual selectivity
The body does not exclusively target fat stores during periods of severe energy restriction
Saleh et al., 2016) sequence was used: TR/TE = 2000/80 ms
FIGURE 2 In addition to direct effects of E2, metabolites resulting from E2 biotransformation, such as catechol estrogens and methoxy estrogens have important biological activity in several different tissues (Park, 2018)
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