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10.1016/j.ijdevneu.2019.05.006 66
Figure 3 3.1 Anti-inflammatory drugs The primary cell type involved in the inflammatory process of bronchiectasis is neutrophils, although eosinophils, lymphocytes and macrophages also contribute significantly to the disease ( 3.1.1 Targeting neutrophils Neutrophil elastase (NE) has the potential to serve as a direct biomarker for neutrophilic inflammation in predicting the risk of future exacerbations ( In vitro experiments have demonstrated that CHF6333 exhibits high selectivity for NE ( Serendex has developed a nebulizer containing Molgramostim, a non-glycosylated form of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF)
J.CapehornM.CharpentierG.DottaF.HenkelE.LingvayI.et al (2018)
In preclinical studies, Glucagon-like peptide-1 (GLP-1) has demonstrated its protective effects in lung disease models, potentially mediated by atrial natriuretic peptide (ANP)
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