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Larger, multicenter trials with balanced cohorts and extended follow-up are required to confirm comparative effects on HbA1c sustainability, beta-cell preservation, and insulin sensitivity

Patients should mark the first-use date on the pen and discard any remaining medication after 6 weeks, even if doses remain

PfK13 mutations have also been shown to be associated with an increased baseline stress response 16, 17, 20

[4] [5] Patients with diabetes who are taking insulin or a sulfonylurea should discuss glucose monitoring and any necessary dose adjustments with their clinician, as improved glycaemic control during treatment may increase hypoglycaemia risk