In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)
Epub 2008 Jul 31
It includes at least 33 sulfur-containing compounds such as alliin, allicin, ajoene, allyl propyl disulfide, diallyl trisulfide, SAC, S-allyl mercaptocysteine, among others as well as many enzymes (alliinase, peroxidase, myrosinase), valuable trace minerals (selenium, germanium, tellurium), and other trace elements [49]
The most common complaints were nausea (55% versus 12.6% with placebo), constipation (30.7% versus 11.6%), and vomiting (26.1% versus 4.1%)