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In an open uncontrolled trial in 20 men with idiopathic infertility and a low testosterone-to-estrogen ratio, three months of treatment with letrozole resulted in improved sperm motility and morphology, reduced sperm DNA fragmentation, increased testosterone-to-estrogen ratio, and four spontaneous pregnancies

The underlying tissue is undergoing active remodeling

Rough estimations point to around 500,000 IMD cases worldwide, causing around 50,000 deaths each year (World Health Organization, 2025)

Additionally, testosterone isnt the only hormone that can become imbalanced in men and lead to sexual wellness struggles