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A long time ago, pernicious anemia was fatal (pernicious means "deadly")
J Biol Chem (2007) 282(48):3540515.10.1074/jbc.M705814200 143 De Rocca Serra-NedelecAEdouardTTreguerKTajanMArakiTDanceMet alNoonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature
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Different techniques are used to ensure quality control of finalized preparation like HPLC (high performance liquid chromatography) or gas chromatography, spectrophotometry, UV detection, measurement of osmolality & pH etc
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